Molecular changes with bipolar disorder identifiedMolecular changes with bipolar disorder identified - March 26, 2008Dr. Bahn, from the University of Cambridge in the UK, and colleagues found that glutamate levels were elevated in the post-mortem brain tissue. In the animal study, treatment with valproate seemed to decrease the glutamate/glutamine ratio, while lithium therapy increased GABA levels. Taken together, the authors note, these findings suggest that the balance of excitatory and inhibitory neurotransmission plays a key role in the pathophysiology of bipolar disorder.
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